How CBD (Cannibidiol) Works

How CBD Works In The Body

CBD works on various receptors through the body activating healing properties...

Cannabidiol (CBD) is is one of the major chemical compounds in the cannabis plant and unlike the other major compound THC found in the same plant cannabidiol (CBD) is non psychoactive. CBD is extracted from the plant using Co2, Ethanol (alcohol) or olive oil extraction procedures.

The Nuts & Bolts Of CBD

CBD is a non-psychoactive pleiotropic drug, this means it produces varied multiple effects through molecular pathways. Mainly interacting with non-cannabinoid receptors and ion channels cannabidiol indirectly stimulates endogenous cannabinoid signaling by suppressing fatty acid amide hydroxylase (FAAH), which is the enzyme that metabolizes anandamide and anandamide is an endogenous cannabinoid that activates the CB1 receptor. So, although CBD does not affect the CB1 and CB2 receptors directly, it does affect them greatly through indirect means.

What are the CB1 and CB2 receptors…

What is so important about the CB1 and CB2 receptors? Humans have cannabinoid receptors throughout the body, lots of them and two of the main ones are CB1 and CB2, these two specific cannabinoid receptors are located throughout the body but are mainly found in the brain and immune system. CBD mainly affects the CB2 receptor which has evidence based potential for treating various pathologies while avoiding the adverse psychoactive effects that can accompany CB1 receptor activation.

CBD (Cannabidiol) targets 5HT1a and TRPV-1 receptors

CBD also acts as an agonist at the 5HT1a receptor, this receptor is already targeted by pharmacologic companies as it's the one of the main serotonin receptors that can combat depression. Cannabidiol also targets, in a positive way, the vanilloid receptor known as TRPV-1 and this receptor also acts as an anti-inflammatory and immunomodulatory agent helping the body’s immune system.

Cannabidiol deactivates the GPR55 receptor…

What's the GRP55 receptor i hear you ask? The GPR55 receptor is a G protein, when the GPR 55 G protein is overactive it has been linked with the promotion of lots of conditions like: bone re-absorption, osteoporosis and cancer cell proliferation. CBD acts as a GPR55 antagonist that deactivates or blocks this protein which is why CBD is used by many cancer patients as a cancer tumour prevention drug because it also activates PPARs (peroxisome proliferator activated receptors).